{"id":240,"date":"2023-06-06T14:57:56","date_gmt":"2023-06-06T05:57:56","guid":{"rendered":"http:\/\/hsc2023.kuas.kagoshima-u.ac.jp\/?page_id=240"},"modified":"2023-06-27T07:59:20","modified_gmt":"2023-06-26T22:59:20","slug":"%e6%8a%84%e8%aa%ad%e4%bc%9apeers%e3%81%a7%e5%8f%96%e3%82%8a%e4%b8%8a%e3%81%92%e3%81%9f%e4%b8%bb%e3%81%aa%e8%ab%96%e6%96%87","status":"publish","type":"page","link":"https:\/\/hsc.kuas.kagoshima-u.ac.jp\/?page_id=240","title":{"rendered":"\u6284\u8aad\u4f1a(PEERS)\u3067\u53d6\u308a\u4e0a\u3052\u305f\u4e3b\u306a\u8ad6\u6587"},"content":{"rendered":"\n<figure class=\"wp-block-table\"><table><tbody><tr><td>&nbsp;<\/td><td>\u5e73\u621029\u5e7410\u670810\u65e5<\/td><td>&nbsp;<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\uff08\u91cd\u8981\uff09<\/strong><br><strong>\u7d71\u5408\u5931\u8abf\u75c7\u6982\u5ff5\u306e\u5d29\u58ca<\/strong><br>Guloksuz S &amp; van Os J. 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Cell 16: 504-510, 2012.<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td>&nbsp;<\/td><td>\u5e73\u621024\u5e747\u670828\u65e5<\/td><td>&nbsp;<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u884c\u52d5\u907a\u4f1d\u5b66\u306e\u6a29\u5a01Plomin\u5148\u751f\u306e\u7dcf\u8aac\u3002\u884c\u52d5\u306b\u95a2\u9023\u3059\u308b\u907a\u4f1d\u5b50\u306e\u767a\u898b\u306f\u672a\u3060\u306b\u9054\u6210\u3055\u308c\u3066\u3044\u306a\u3044\u3002\u8eab\u9577\u306e\u591a\u69d8\u6027\u306e90\uff05\u306f\u907a\u4f1d\u6027\u3067\u3042\u308b\u304c\u3001\u8907\u6570\u306e\u907a\u4f1d\u7d20\u56e0\u306e\u52b9\u679c\u30b5\u30a4\u30ba\u3092\u5168\u90e8\u5408\u308f\u305b\u3066\u3082\u6700\u5927\u591a\u69d8\u6027\u306e10\uff05\u3057\u304b\u8aac\u660e\u3067\u304d\u306a\u3044\u3002\u884c\u52d5\u5b66\u7684\u5f62\u8cea\u306e\u907a\u4f1d\u6027\u306f\u7d0450\uff05\u3067\u3042\u308b\u3082\u306e\u304c\u591a\u3044\u304c\u3001\u8a8d\u77e5\u767a\u9054\u306e\u5168\u30b2\u30ce\u30e0\u95a2\u9023\u7814\u7a76\u306e\u7d50\u679c\u3067\u3082\u591a\u69d8\u6027\u306e\uff15\uff05\u4ee5\u4e0b\u3092\u8aac\u660e\u3057\u3066\u3044\u308b\u306b\u904e\u304e\u306a\u3044\u3002\u81ea\u9589\u75c7\u3068\u7d71\u5408\u5931\u8abf\u75c7\u3067\u306f\u3001\u89aa\u306b\u307f\u3089\u308c\u306a\u3044\uff08de novo\uff09\u5909\u7570\u306e\u51fa\u73fe\u304c\u8a71\u984c\u306b\u306a\u3063\u3066\u3044\u308b\u304c\u3001de novo\u5909\u7570\u306f\u3053\u306e\u2018\u6d88\u3048\u305f\u907a\u4f1d\u6027\u554f\u984c\u2019\u3092\u5168\u304f\u8aac\u660e\u3067\u304d\u306a\u3044\u3002<\/strong><br>Plomin R. Child development and molecular genetics: 14 years later. Child Development 84: 104-120, 2013.<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td>&nbsp;<\/td><td>\u5e73\u621024\u5e746\u670830\u65e5<\/td><td>&nbsp;<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u30a8\u30af\u30bd\u30f3\u90e8\u306e\u907a\u4f1d\u5b50\u914d\u5217\u89e3\u6790\u3002\u8868\u73fe\u578b\u4e0d\u4e00\u81f4\u5144\u5f1f\u3092\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u7fa4\u3068\u3057\u3066\u3001\u5bb6\u65cf\u30c7\u30fc\u30bf\u3067\u767a\u7aef\u8005\u306b\u51fa\u73fe\u3057\u305f\uff08de novo\uff09\u5909\u7570\u307e\u3067\u6bd4\u8f03\u691c\u8a0e\u3002de novo\u5909\u7570\u3060\u3051\u306b\u6709\u610f\u5dee\u304c\u3042\u308a\u3001\u30a2\u30df\u30ce\u9178\u5909\u7570\u306e\u3042\u308bde novo\u5909\u7570\u3068\u7d42\u6b62\u30b3\u30c9\u30f3\u304c\u51fa\u73fe\u3059\u308bde novo\u5909\u7570\u3067\u3082\u6709\u610f\u5dee\uff08\u7279\u306b\u5927\u8133\u3067\u767a\u73fe\u3059\u308b\u907a\u4f1d\u5b50\uff09\u3002\u30ca\u30c8\u30ea\u30a6\u30e0\u30c1\u30e3\u30f3\u30cd\u30eb\u306e\u907a\u4f1d\u5b50\uff08SCN2A\uff09\u306b\u7d42\u6b62\u30b3\u30c9\u30f3\u304c\u3067\u304d\u308b\u5909\u7570\u3092\u6301\u3064\u4f8b\u304c\uff12\u4f8b\u3042\u308a\u3001\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u7fa4\u3067\u306f\u4e00\u4f8b\u3082\u306a\u304b\u3063\u305f\u3002\uff08\u6ce8\uff1a\u305d\u308c\u305e\u308c\u306e\u5909\u7570\u304c\u8aac\u660e\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u81ea\u9589\u75c7\u306f\uff11\u4f8b\u306e\u307f\u3002\u8907\u6570\u306e\u5909\u7570\u304c\u3042\u308b\u5834\u5408\u304c\u81ea\u9589\u75c7\u306b\u591a\u3044\u8a33\u3067\u306f\u306a\u3044\u3002\uff09<\/strong><br>Sanders SJ, et al. De novo mutations revealed by whole-exome sequencing are strongly associated with autism. Nature 485: 237-241, 2012.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u30a8\u30af\u30bd\u30f3\u90e8\u306e\u907a\u4f1d\u5b50\u914d\u5217\u89e3\u6790\u3002de novo\u5909\u7570\u3092\u691c\u8a0e\u3002\u81ea\u9589\u75c7\u30b9\u30da\u30af\u30c8\u30e9\u30e0\u306e46.3\uff05\u306e\u30b1\u30fc\u30b9\u304c\u3001\u30a2\u30df\u30ce\u9178\u5909\u7570\u306e\u3042\u308b\u3001\u307e\u305f\u306f\u7d42\u6b62\u30b3\u30c9\u30f3\u304c\u51fa\u73fe\u3059\u308b\u4f55\u3089\u304b\u306ede novo\u5909\u7570\u3092\u6301\u3064\u304c\u3001\u89b3\u5bdf\u3055\u308c\u308bde novo\u30a4\u30d9\u30f3\u30c8\u306e\u591a\u304f\u306f\u81ea\u9589\u75c7\u30b9\u30da\u30af\u30c8\u30e9\u30e0\u306b\u3064\u306a\u304c\u3063\u3066\u3044\u308b\u3068\u306f\u9650\u3089\u306a\u3044\u3002\u3053\u306e\u7d50\u679c\u306f\u591a\u907a\u4f1d\u5b50\u30e2\u30c7\u30eb\u3092\u652f\u6301\u3059\u308b\u3002\uff08\u6ce8\uff1a\u5831\u544a\u3055\u308c\u3066\u3044\u308bde novo\u5909\u7570\u306e\u90e8\u4f4d\u306f\u5358\u306a\u308b\u30db\u30c3\u30c8\u30b9\u30dd\u30c3\u30c8\uff1f\uff09<\/strong><br>Neale BM. et al. Patterns and rates of exonic de novo mutations in autism spectrum disorders. Nature 485: 242-245, 2012.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u30a8\u30af\u30bd\u30f3\u90e8\u306e\u907a\u4f1d\u5b50\u914d\u5217\u89e3\u6790\u3067de novo\u5909\u7570\u3092\u691c\u8a0e\u3002de novo\u5909\u7570\u306f\u7cbe\u5b50\u7531\u6765\u304c\u307b\u3068\u3093\u3069\uff08\uff14\uff1a\uff11\uff09\u3067\u3001\u7236\u89aa\u306e\u5e74\u9f62\u3068\u76f8\u95a2\u3002\u7834\u7dbb\u7684de novo\u5909\u7570\u306e39\uff05\u304c\u03b2-catenin\/chromatin remodeling\u86cb\u767d\u306e\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u3002CHD8\u3068NTNG1\u4e0a\u306b\u30a2\u30df\u30ce\u9178\u5909\u7570\u3092\u304d\u305f\u3059\u5909\u7570\u304c\u3042\u308b\u4f8b\u304c\uff12\u4f8b\u305a\u3064\u3002\u5019\u88dc\u907a\u4f1d\u5b50\u306b\u95a2\u3059\u308b\u5909\u7570\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3067\u3001GRIN2B\u3068LAMC3\u3068SCN1A\u306b\u30a2\u30df\u30ce\u9178\u5909\u5316\u3092\u4f34\u3046de novo\u5909\u7570\u3002\uff08\u6ce8\uff1a\u305d\u308c\u305e\u308c\u306e\u5909\u7570\u304c\u8aac\u660e\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u81ea\u9589\u75c7\u306f\uff11\u4f8b\u304b\uff12\u4f8b\u306e\u307f\u3002\uff09<\/strong><br>O&#8217;Roak BJ, et al. Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations. Nature 485: 246-250, 2012.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u30a8\u30af\u30bd\u30f3\u90e8\u306e\u907a\u4f1d\u5b50\u914d\u5217\u89e3\u6790\u3002\u5b64\u767a\u4f8b\u306e\u691c\u8a0e\u3067\u3001\u9060\u3044\u5148\u7956\u3092\u5171\u6709\u3059\u308b\u81ea\u9589\u75c7\u767a\u7aef\u8005\u3092\u540c\u5b9a\u3059\u308b\u30db\u30e2\u63a5\u5408\u6027\u89e3\u6790\u3067\u691c\u8a0e\u3002\u3053\u306e\u65b9\u6cd5\u306f\u907a\u4f1d\u7d20\u56e0\u304c\u52a3\u6027\u3067\u3042\u308b\u6642\u6709\u52b9\u300216\u5bb6\u7cfb\u4e2d\uff14\u5bb6\u7cfb\u306b\u304a\u3044\u3066\u81ea\u9589\u75c7\u5f62\u8cea\u3068\u3044\u3063\u3057\u3087\u306b\u4f1d\u642c\u3055\u308c\u3066\u3044\u308b\u30db\u30e2\u63a5\u5408\u6027\u5909\u7570\u304c\u78ba\u8a8d\u3055\u308c\u305f\u3002\u5019\u88dc\u907a\u4f1d\u5b50\uff08UBE3B, CLTCL1, NCKAP5L, ZNF18\uff09\u306f\u3001\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u3084\u7d30\u80de\u9aa8\u683c\u69cb\u6210\u306b\u95a2\u9023\u3057\u3001\u30cb\u30e5\u30fc\u30ed\u30f3\u306e\u8131\u5206\u6975\u306b\u3088\u308a\u305d\u306e\u8ee2\u5199\u304c\u5236\u5fa1\u3002\uff08\u6ce8\uff1a\u52a3\u6027\u907a\u4f1d\u7d20\u56e0\u3092\u7279\u7570\u7684\u306b\u691c\u51fa\uff1f\u30db\u30e2\u63a5\u5408\u6027\u90e8\u4f4d\u306f\u5909\u7570\u306e\u30db\u30c3\u30c8\u30b9\u30dd\u30c3\u30c8\uff1f\uff09<\/strong><br>Chahrour MH, et al. Whole-exome sequencing adn homozygosity analysis implicate depolarization-regulated neuronal genes in autism. PLoS Genetics 8: e1002635, 2012.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u30db\u30e2\u63a5\u5408\u6027\uff08\u30cf\u30d7\u30ed\u30bf\u30a4\u30d7\uff09\u89e3\u6790\u3002\u30db\u30e2\u63a5\u5408\u4f53\u30cf\u30d7\u30ed\u30bf\u30a4\u30d7\u90e8\u4f4d\u306f\u3001\u3053\u308c\u307e\u3067\u306b\u5831\u544a\u3055\u308c\u305f\u81ea\u9589\u75c7\u30b9\u30da\u30af\u30c8\u30e9\u30e0\u5019\u88dc\u907a\u4f1d\u5b50\u306b\u6709\u610f\u306b\u8c4a\u5bcc\u3002\uff08\u6ce8\uff1a\u30db\u30e2\u63a5\u5408\u6027\u306f\u30d6\u30ed\u30bf\u30a4\u30d7\u306f\u5909\u7570\u306e\u30db\u30c3\u30c8\u30b9\u30dd\u30c3\u30c8\uff1f\uff09<\/strong><br>Casey JP, et al. A novel approach of homozygous haplotype sharing identifies candidate genes in autism spectrum disorder. Hum Genet 131: 565-579, 2012.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u81ea\u9589\u75c7\u306b\u95a2\u9023\u3057\u3066\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u3001\u30b7\u30ca\u30d7\u30b9\u69cb\u9020\u86cb\u767d\uff08\u8db3\u5834\u86cb\u767d\uff09\u306e\u907a\u4f1d\u5b50\u3067\u3042\u308bSHANK2\u306e\u5909\u7570\u30de\u30a6\u30b9\u3092\u4f5c\u88fd\u3002\u793e\u4f1a\u7684\u306a\u76f8\u4e92\u95a2\u4fc2\u306e\u6e1b\u5c11\u3001\u30b3\u30df\u30e5\u30cb\u30b1\u30fc\u30b7\u30e7\u30f3\uff08\u6c42\u611b\uff09\u884c\u52d5\u306e\u6e1b\u5c11\u3001\u304a\u3088\u3073\u53cd\u5fa9\u6027\u306e\u30b8\u30e3\u30f3\u30d7\u884c\u52d5\u306e\u51fa\u73fe\u304c\u307f\u3089\u308c\u305f\u3002\u307e\u305f\u3001\u30b0\u30eb\u30bf\u30df\u30f3\u9178\u53d7\u5bb9\u4f53\uff08NMDAR\uff09\u306e\u6a5f\u80fd\u4f4e\u4e0b\u3082\u307f\u3089\u308c\u305f\u3002NMDAR\u306e\u90e8\u5206\u7684\u30a2\u30b4\u30cb\u30b9\u30c8\u3067\u523a\u6fc0\u3059\u308b\u3068\u3001NMDAR\u6a5f\u80fd\u304c\u6b63\u5e38\u5316\u3057\u3001\u793e\u4f1a\u7684\u76f8\u4e92\u95a2\u4fc2\u304c\u6539\u5584\u3057\u305f\u3002\u307e\u305f\u3001\u4ee3\u8b1d\u578b\u30b0\u30eb\u30bf\u30df\u30f3\u9178\u53d7\u5bb9\u4f53\uff15\u306e\u6d3b\u6027\u5316\u3092\u4ecb\u3057\u3066NMDAR\u6a5f\u80fd\u3092\u5897\u5f37\u3059\u308b\u56e0\u5b50\u306b\u3088\u308b\u524d\u51e6\u7406\u3067\u3082\u540c\u69d8\u306a\u7d50\u679c\u3002<\/strong><br>Won H, et al. Autistic-like social behaviour in Shank2-mutant mice improved by restoring NMDA receptor function. Nature 486: 261-265, 2012.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Shank2\u6b20\u640d\u30de\u30a6\u30b9\u3002Shank2\u3092\u6b20\u640d\u3055\u305b\u308b\u3068\u3001Shank3\u306e\u86cb\u767d\u30ec\u30d9\u30eb\u304c\u5897\u52a0\u3057\u3001\u6a39\u72b6\u7a81\u8d77\u306e\u6e1b\u5c11\u3001\u30b7\u30ca\u30d7\u30b9\u4f1d\u9054\u306e\u6e1b\u5c11\u3001\u5fae\u5c0f\u8208\u596e\u6027\u5f8c\u30b7\u30ca\u30d7\u30b9\u96fb\u6d41\u306e\u983b\u5ea6\u306e\u6e1b\u5c11\u3001NMDAR\u304c\u4ef2\u4ecb\u3059\u308b\u8208\u596e\u6027\u96fb\u6d41\u306e\u751f\u7406\u7684\u30ec\u30d9\u30eb\u3067\u306e\u5897\u5f37\u3001\u306a\u3069\u304c\u8d77\u3053\u308b\u3002\u5909\u7570\u30de\u30a6\u30b9\u306f\u6975\u7aef\u306b\u591a\u52d5\u3067\u3001\u6df1\u523b\u306a\u81ea\u9589\u75c7\u69d8\u884c\u52d5\u3092\u5448\u3057\u305f\u3002Shank3\u6b20\u640d\u3067\u306f\u3001\u904b\u52d5\u6e1b\u5c11\u3084\u53cd\u5fa9\u884c\u52d5\u306a\u3069\u304c\u307f\u3089\u308c\u305f\u3002<\/strong><br>Schmeisser MJ, et al. 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J Am Acad Child Adolesc Psychiatry 51: 347-349, 2012.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>DSM-5\uff08\u30c9\u30e9\u30d5\u30c8\uff09\u306f\u3001\u7279\u7570\u5ea6\u306b\u304a\u3044\u3066\u306f\u826f\u304f\u306a\u3063\u3066\u3044\u308b\u304c\u3001\u8a8d\u77e5\u80fd\u529b\u306e\u9ad8\u3044\u30b1\u30fc\u30b9\u306e\u304b\u306a\u308a\u306e\u90e8\u5206\u3092\u9664\u5916\u3057\u3001\u81ea\u9589\u6027\u969c\u5bb3\uff08DSM-IV-TR\uff09\u4ee5\u5916\u306e\u30b5\u30d6\u30bf\u30a4\u30d7\u3092\u304b\u306a\u308a\u9664\u5916\u3057\u3066\u3057\u307e\u3046\u3002<\/strong><br>McPartland JC, et al. Sensitivity and specificity of proposed DSM-5 diagnostic criteria for autism spectrum disorder. J Am Acad Child Adolesc Psychiatry 51: 368-383, 2012.<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td>&nbsp;<\/td><td>\u5e73\u621024\u5e743\u670810\u65e5<\/td><td>&nbsp;<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\uff08\u91cd\u8981\uff09<\/strong><br><strong>\u5c0f\u5150\u671f\u306e\u81ea\u9589\u75c7\u5f62\u8cea\u306f\u3001\u601d\u6625\u671f\u306b\u304a\u3051\u308b\u7cbe\u795e\u75c5\u6027\u4f53\u9a13\uff08psychotic experiences\uff09\u306b\u95a2\u9023\u3057\u3066\u3044\u308b\u3002\u3053\u306e\u3053\u3068\u306f\u3001\u80cc\u666f\u306b\u3042\u308b\u539f\u56e0\u304c\u540c\u4e00\u3067\u3042\u308b\u304b\u3001\u3042\u308b\u3044\u306f\u81ea\u9589\u75c7\u5f62\u8cea\u304c\u7cbe\u795e\u75c5\u4f53\u9a13\u306e\u65e9\u671f\u524d\u99c6\u72b6\u614b\u3067\u3042\u308b\u3053\u3068\u306b\u3088\u308b\u306e\u304b\u3082\u3057\u308c\u306a\u3044\u3002<\/strong><br>Jones RB, et al. 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Schizophrenia Research 135: 164-169, 2012.<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td>&nbsp;<\/td><td>\u5e73\u621024\u5e741\u670821\u65e5<\/td><td>&nbsp;<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\uff08\u91cd\u8981\uff09<\/strong><br><strong>\u81ea\u9589\u75c7\u305d\u306e\u3082\u306e\u3092\u6cbb\u7642\u304c\u5fc5\u8981\u306a\u969c\u5bb3\u3068\u3057\u3066\u3068\u3089\u3048\u308b\u3053\u3068\u306f\u9069\u5207\u3067\u306f\u306a\u3044\u3002\u81ea\u9589\u75c7\u306e\u751f\u7269\u5b66\u7684\u30de\u30fc\u30ab\u30fc\u3092\u8ffd\u6c42\u3059\u308b\u3053\u3068\u306b\u306f\u502b\u7406\u7684\u306a\u9650\u754c\u304c\u5b58\u5728\u3059\u308b\u3002\u5358\u72ec\u306e\u907a\u4f1d\u5b50\u307e\u305f\u306f\u907a\u4f1d\u5b50\u306e\u30bb\u30c3\u30c8\u306e\u7834\u7dbb\u3067\u3001\u81ea\u9589\u75c7\u3068\u3044\u3046\u72b6\u614b\u3092\u78ba\u5b9f\u306b\u4e88\u6e2c\u3059\u308b\u3053\u3068\u306f\u3067\u304d\u306a\u3044\u3002<\/strong><br>Editorials. 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Nature 479: 22-24, 2011.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\uff08\u91cd\u8981\uff09<\/strong><br><strong>\u4f3c\u305f\u8005\u540c\u58eb\u5a5a\u8aac\uff08Baron-Cohen\uff09\u3002\u81ea\u9589\u75c7\u8005\u306f\u6a5f\u68b0\u5de5\u5b66\u3001\u6570\u5b66\u3001\u30b3\u30f3\u30d4\u30e5\u30fc\u30bf\u30d7\u30ed\u30b0\u30e9\u30e0\u306a\u3069\u306e\u79d1\u5b66\u5206\u91ce\u306b\u8ca2\u732e\u3057\u3066\u3044\u308b\u3002<\/strong><br>Buchen L. When geeks meet. Nature 479:25-27, 2011.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\uff08\u91cd\u8981\uff09<\/strong><br><strong>\u79d1\u5b66\u3092\u542b\u3080\u7279\u5b9a\u306e\u5206\u91ce\u3067\u306f\u3001\u81ea\u9589\u75c7\u3067\u3042\u308b\u3053\u3068\u304c\u3080\u3057\u308d\u5f37\u307f\u3067\u3042\u308a\u5f97\u308b\u3002\u8996\u899a\u7684\u306a\u30d1\u30bf\u30fc\u30f3\u3092\u5b8c\u6210\u3055\u305b\u308b\u8ab2\u984c\u3067\u5206\u6790\u7684\u77e5\u80fd\u3092\u8a55\u4fa1\u3059\u308bRaven\u30de\u30c8\u30ea\u30c3\u30af\u30b9\u30c6\u30b9\u30c8\u3067\u306f\u3001\u81ea\u9589\u75c7\u8005\u306f\u77e5\u7684\u969c\u5bb3\u3067\u306a\u3044\u3070\u304b\u308a\u304b\u3001\u5834\u5408\u306b\u3088\u3063\u3066\u306f\u5065\u5e38\u8005\u3088\u308a\u512a\u308c\u3066\u3044\u308b\u3002<\/strong><br>Mottron L. The power of autism. 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